Comparative effects of L-arginine and vitamin C on gentamicin-induced alterations in some biochemical indices of kidney function

Kidney injury is an adverse effect of gentamicin which limits its use as antimicrobial agent. Finding antidote for this will reduce the number cases kidney that accompany gentamicin. This study compares effects L-arginine and vitamin C on gentamicin-induced in Wistar rats. Rats were assigned to 5 groups (n=6). Groups I V treated respectively with distilled water, gentamicin, L-arginine, After 14-day treatment, animals euthanized plasma creatinine, urea, protein, potassium, urinary malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) analyzed. Administration increased levels MDA significantly (p < 0.05) compared water-treated group. The SOD GPx reduced 0.05). Treatment C, combined potassium MDA. Plasma SOD, raised control. results indicate more effective than reversing biochemical changes, but produced even ameliorative effect. Therefore, taking during therapy may incidence injury.